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A suite of applications built on InterSystems IRIS data platform and optimized to address industry specific challenges.
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Analytics solution that provides real-time care insights and in-depth analysis for clinical, business, and population health management.
A next-generation enterprise master person index – an automated, easily integrated solution for identity resolution.
A reimagined EHR with built-in GenAI that empowers clinicians, enhances patient experiences, and elevates business operations.
Helps clinicians, care managers, and care teams strengthen coordination, enhance continuity of care, and improve patient engagement in under-served rural areas.
Enables health systems, independent providers, health plans, HIEs, governments and software developers to create a digital front door.
Collects, consolidates, and publishes information about healthcare providers' relationships to patients, health plans, and one another.
A powerful, flexible electronic health record (EHR) that supports all leading health information interoperability standards and profiles.
Enterprise solution supports any clinical lab service, public or private, independent to extensive national laboratory systems.
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A suite of low code platforms built on InterSystems IRIS and optimized to address industry-specific challenges.
An aggregated, normalized and deduplicated patient record created from patient data across multiple sources.
A high-availability, high-performance integration engine created specifically for healthcare.
A cloud-based data pipeline and management solution combining FHIR with an out-of-the-box transformation to the CDM and OMOP repository.
One integration that standardizes data exchange between Epic Payer Platform and your clinical and administrative applications.
Interoperability solutions designed to help U.S. health insurers address CMS-0057 and CMS-9115.
Platforms & Components
Versatile foundation supporting a range of solutions, with built-in APIs for integration.
Rapidly access & use FHIR data from diverse sources without the need to create your own FHIR computing infrastructure.
A high-performance data platform designed to make it easy to build applications that support mission-critical processes.
Fully managed cloud-native SaaS offerings that provide customers the fastest time to value for InterSystems data management software.
A digital health data platform that provides the building blocks needed to work with any healthcare data standard, including FHIR.
An AI-enabled supply chain decision intelligence platform that predicts disruptions before they occur, and optimally handles when they do.
Healthcare
InterSystems HL7 FHIR-based technology and solutions power success for organizations across the entire healthcare ecosystem.
A cloud-based, on-demand service delivering near real-time, secure access to patient data from across the nation.
A suite of solutions that work together to capture information, share it in a meaningful way, aid understanding, and drive transformative action.
Analytics solution that provides real-time care insights and in-depth analysis for clinical, business, and population health management.
Rapidly access & use FHIR data from diverse sources without the need to create your own FHIR computing infrastructure.
A high-availability, high-performance integration engine created specifically for healthcare.
A reimagined EHR with built-in GenAI that empowers clinicians, enhances patient experiences, and elevates business operations.
A digital health data platform that provides the building blocks needed to work with any healthcare data standard, including FHIR.
A cloud-based data pipeline and management solution combining FHIR with an out-of-the-box transformation to the CDM and OMOP repository.
One integration that standardizes data exchange between Epic Payer Platform and your clinical and administrative applications.
Interoperability solutions designed to help U.S. health insurers address CMS-0057 and CMS-9115.
Helps clinicians, care managers, and care teams strengthen coordination, enhance continuity of care, and improve patient engagement in under-served rural areas.
A powerful, flexible electronic health record (EHR) that supports all leading health information interoperability standards and profiles.
Enterprise solution supports any clinical lab service, public or private, independent to extensive national laboratory systems.
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Enabling firms to transform at scale, so they can increase customer satisfaction, adopt generative AI, maintain compliance, grow revenue, and optimize efficiency.
A high-performance data platform designed to make it easy to build applications that support mission-critical processes.
The fastest way for financial services firms to break down silos and transform disparate data into a single unified resource of actionable information.
Launch new funds, accelerate AI initiatives, automate reporting with a self-service solution tailor-made for asset management firms.
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An AI-enabled supply chain decision intelligence platform that predicts disruptions before they occur, and optimally handles when they do.
A data gateway that speeds and simplifies data access for supply chain applications and practitioners.
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InterSystems and Google Cloud empower you to quickly build new apps or modernize existing ones to increase agility and reap the benefits of the multicloud.
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Products
By Type
By Industry
Applications
A suite of applications built on InterSystems IRIS data platform and optimized to address industry specific challenges.
A FHIR®-enabled care management software solution that allows the entire care team to create and share comprehensive care plans.
A cloud-based, on-demand service delivering near real-time, secure access to patient data from across the nation.
Analytics solution that provides real-time care insights and in-depth analysis for clinical, business, and population health management.
A next-generation enterprise master person index – an automated, easily integrated solution for identity resolution.
A reimagined EHR with built-in GenAI that empowers clinicians, enhances patient experiences, and elevates business operations.
Helps clinicians, care managers, and care teams strengthen coordination, enhance continuity of care, and improve patient engagement in under-served rural areas.
Enables health systems, independent providers, health plans, HIEs, governments and software developers to create a digital front door.
Collects, consolidates, and publishes information about healthcare providers' relationships to patients, health plans, and one another.
A powerful, flexible electronic health record (EHR) that supports all leading health information interoperability standards and profiles.
Enterprise solution supports any clinical lab service, public or private, independent to extensive national laboratory systems.
Low Code Platforms
A suite of low code platforms built on InterSystems IRIS and optimized to address industry-specific challenges.
An aggregated, normalized and deduplicated patient record created from patient data across multiple sources.
A high-availability, high-performance integration engine created specifically for healthcare.
A cloud-based data pipeline and management solution combining FHIR with an out-of-the-box transformation to the CDM and OMOP repository.
One integration that standardizes data exchange between Epic Payer Platform and your clinical and administrative applications.
Interoperability solutions designed to help U.S. health insurers address CMS-0057 and CMS-9115.
Platforms & Components
Versatile foundation supporting a range of solutions, with built-in APIs for integration.
Rapidly access & use FHIR data from diverse sources without the need to create your own FHIR computing infrastructure.
A high-performance data platform designed to make it easy to build applications that support mission-critical processes.
Fully managed cloud-native SaaS offerings that provide customers the fastest time to value for InterSystems data management software.
A digital health data platform that provides the building blocks needed to work with any healthcare data standard, including FHIR.
An AI-enabled supply chain decision intelligence platform that predicts disruptions before they occur, and optimally handles when they do.
Healthcare
InterSystems HL7 FHIR-based technology and solutions power success for organizations across the entire healthcare ecosystem.
A cloud-based, on-demand service delivering near real-time, secure access to patient data from across the nation.
A suite of solutions that work together to capture information, share it in a meaningful way, aid understanding, and drive transformative action.
Analytics solution that provides real-time care insights and in-depth analysis for clinical, business, and population health management.
Rapidly access & use FHIR data from diverse sources without the need to create your own FHIR computing infrastructure.
A high-availability, high-performance integration engine created specifically for healthcare.
A reimagined EHR with built-in GenAI that empowers clinicians, enhances patient experiences, and elevates business operations.
A digital health data platform that provides the building blocks needed to work with any healthcare data standard, including FHIR.
A cloud-based data pipeline and management solution combining FHIR with an out-of-the-box transformation to the CDM and OMOP repository.
One integration that standardizes data exchange between Epic Payer Platform and your clinical and administrative applications.
Interoperability solutions designed to help U.S. health insurers address CMS-0057 and CMS-9115.
Helps clinicians, care managers, and care teams strengthen coordination, enhance continuity of care, and improve patient engagement in under-served rural areas.
A powerful, flexible electronic health record (EHR) that supports all leading health information interoperability standards and profiles.
Enterprise solution supports any clinical lab service, public or private, independent to extensive national laboratory systems.
Financial Services
Enabling firms to transform at scale, so they can increase customer satisfaction, adopt generative AI, maintain compliance, grow revenue, and optimize efficiency.
A high-performance data platform designed to make it easy to build applications that support mission-critical processes.
The fastest way for financial services firms to break down silos and transform disparate data into a single unified resource of actionable information.
Launch new funds, accelerate AI initiatives, automate reporting with a self-service solution tailor-made for asset management firms.
Supply Chain
Empowering organizations with real-time supply chain visibility and the ability to make optimized, real-time, AI-driven decisions.
An AI-enabled supply chain decision intelligence platform that predicts disruptions before they occur, and optimally handles when they do.
A data gateway that speeds and simplifies data access for supply chain applications and practitioners.
Knowledge Hub
Developer Websites
New to InterSystems? Start here, this is your gateway to developer sites, tutorials and more.
Connect, grow, share. The developer community is full of resources, news, and events and a community of people to connect with.
Everything you need to know about our products and more.
Develop. Learn. Share. Network. All with InterSystems Global Masters program where you can join an engaged community of developers.
Experience first hand the community’s dedication to the evolution of our technology with applications.
Education
Get to know InterSystems products and technologies your way, with self-paced online materials and classroom courses.
Online learning presents self-paced materials to help you build and support your organization's most critical applications.
In-person courses maximize learning in a distraction-free environment with face-to-face engagement.
InterSystems proudly supports the free use of InterSystems products for university and college coursework.
View the full list of course offerings and our current course schedule.
Certification
Offers industry-standard exams, flexible testing options, certification badges, and career advancement opportunities demonstrating expertise in InterSystems technologies.
InterSystems Learning Services offers industry-standard certification exams that allow you to prove your mastery of our technology.
Digital credentials that represent the varying levels of achievement you can earn with InterSystems.
Everything you need to know about preparing for, scheduling, and taking InterSystems Exams.
Retake Policies & Support, Beta Exams and more.
Answers to common questions regarding exams, including exam preparation, practice exams, retaking exams, and certifications.
InterSystems Blogs
Explore InterSystems blogs featuring expert insights, industry trends, technology innovations, data management strategies, and thought leadership.
Healthcare industry experts talk about pressing challenges, issues, and trends at the intersection of healthcare and technology.
Addressing various business, data, and technology-related issues for the line of business.
Partners
Partner Programs
Our partners ensure that organizations around the globe are already ready for tomorrow’s opportunities.
Bring together people, processes and technology to deliver solutions that solve complex customer challenges.
Combine your expertise with our proven data, analytics and interoperability capabilities to deliver optimal solutions.
Specialists whose services and guidance ensure consistent, effective delivery of InterSystems technology.
Provide complementary tools and platforms that strengthen and expand our technologies' capabilities.
InterSystems powers data-driven digital startups across healthcare, financial services, and supply chain.
Cloud Partners
InterSystems works with the world's leading cloud providers to give customers the freedom to deploy our technology where it delivers the most value.
The speed, scale, and capabilities of InterSystems and AWS can streamline operations, improve access to data and power breakthrough applications.
InterSystems IRIS and InterSystems IRIS for Health Data Platforms are Preferred Solutions on Azure Marketplace.
InterSystems and Google Cloud empower you to quickly build new apps or modernize existing ones to increase agility and reap the benefits of the multicloud.
InterSystems works with the world’s leading cloud providers - including Amazon Web Services (AWS), Microsoft Azure, Google Cloud, TenCent and Alibaba
Company
About Us
Our technologies provide the connective tissue that transforms disparate data into a single, complete view, enabling better outcomes.
News
News and resources for media including press releases, media kits, tools and more.
The latest news and coverage from our corporate headquarters in Boston, MA.
Core information about InterSystems, our background, our products and technologies, and more.
Please contact Corporate Affairs & Communications regarding media inquiries.
Events
Check out conferences and events we're hosting and attending, and view on-demand content for anything you missed.
Browse our upcoming conference and event schedule to see where we'll be and what we'll be covering.
View our library of on-demand content, including keynote speeches from InterSystems READY, webinars and live event footage.
Watch keynote presentations from InterSystems READY 2026.
Support
Product Support
We provide expert technical assistance to customers 24 hours a day, every day, with support advisors in 15 countries.
Read about support alerts, critical issues, fixes, and product releases.
Access current and previous versions and related notes for InterSystems products.
Contact the WRC for Immediate Help
Documentation
Detailed technical information for InterSystems products, technologies, solutions, and more.
Search to learn about InterSystems products and solutions, career opportunities, and more.

Manifest MedEx: Cutting Through the Noise to Deliver Insights

Manifest MedEx

Claudia Williams opened up More Signal, Less Noise, an educational session presented at HIMSS19 in Orlando, by offering the following observation: “Walking through the showcase floor, I see the language has shifted from electronic health records to population health. That represents a massive transition in our healthcare system to one that pays for value. Not just what happens in your clinic, but also what happens outside your clinic is your responsibility. In that context, gaps in data are gaps in insight. And gaps in insight literally can cause these [value-based] models to fail.”

Manifest MedEx, California’s nonprofit health data network where Williams serves as CEO, exists to help healthcare organizations avert such failure. “Our mission is to serve every provider across the state with the data and insight needed to improve care, reduce costs, and, in the end, improve health,” Williams said.

To accomplish this, Manifest MedEx is “bringing together claims and clinical data and trying to make sense of it in a way that delivers value to healthcare providers,” said Erica Galvez, the organization’s Chief Strategy Officer. Available data include patient encounters and procedures, hospital admission and discharge information, care team, diagnoses, lab results, imaging reports, medications, and allergies.

Sifting Through the ‘Noise’ for Actionable, Timely Data
The challenge is to take “large volumes of data, which often represent a lot of noise, and find signal in that noise so that providers can make use of it,” said Galvez. When working with data, the signal carries the information of interest, while the remaining data acts as noise and detracts users from understanding the relevant information.

“If we can drill down to about five pieces of information for providers and deliver those five pieces of information in a timely manner, it enables them to take action that actually saves lives,” Galvez said.

Indeed, medical providers don’t want more data, according to Williams. “I can’t tell you how many times I’ve talked to doctors, and they say, ‘Don’t give me more data. Whatever you do, don’t give me more data. Give me an insight that I can take action on,’” she said.

A pediatric practice, for example, might not have much need to obtain information on hospital admissions and discharges. However, a significant number of the practice’s asthmatic patients might visit the emergency room. So a signal indicating when patients wind up in the ER could help pediatricians work more closely with patients who need to better control their asthma, thereby reducing the number of ER visits.

Integrated Data Leads to Better Care
Creating meaningful signals often requires relying on integrated data. For example, when pharmacy claims information is combined with clinical information, Manifest MedEx is able “to tell participants not only what medication was prescribed for a patient from the clinical data perspective, but also which prescriptions the patient filled,” Galvez said. This signal could help healthcare providers “engage in a more robust medication reconciliation process” and also “follow up with patients proactively for medication compliance.”

MX data are helping one of their ACO participants provide better care for its patients and succeed in reducing readmissions and total cost of care. The provider organization relies on MX real-time hospital event notifications to identify when a patient has been hospitalized and then drills down into information in the patient’s longitudinal health records to uncover patterns and causes. When a care manager in the network discovers that a patient is being admitted to the hospital repeatedly because of falls, she can ensure that the patient has a walker when he or she arrives at home. She can also deploy a caregiver who can “make sure the patient knows how to use the walker, understands the discharge instructions, and understands what medications are supposed to be taken,” Galvez said.

Analytics can help “ask questions of the data and find signals that we didn’t even know we should be looking for,” Galvez said. “We are leveraging this massive volume of information to predict things such as: What’s the likelihood that your patient will be readmitted or admitted? What’s the likelihood that the cost for this patient will increase over the course of the year?” With this type of analysis, according to Galvez, care managers can “transform the discharge planning process to make sure that each patient comes out of the hospital thinking about all of those risk points and making sure that person has the resources needed as he or she goes home.”

Ironically, though, to arrive at these “narrow slices of insight,” Galvez noted, “we have to have massive volumes of data. We have to suffer through a lot of noise.”

Manifest-MedEx-partnership-video-thumb

 

Building the Foundation
To successfully work with all this data, the health data network has established an infrastructure that makes it possible to aggregate more than four years of data from about eight million lives and then “find the needle in the haystack, if you will, across all that information and glean those insights that live within data,” said David Kates, the Manifest MedEx CTO. To create this infrastructure, the company is relying on a data warehouse and clinical data repository from InterSystems, as well as an interface engine from Rhapsody and an enterprise master-patient index from NextGate.

The infrastructure makes it possible to not only aggregate data, but also to “rationalize it, make sense of the different terminology...and create consistency around that data so you can make decisions and apply analytics in order to derive insights,” said Kates.

What’s more, Manifest MedEx is leveraging FHIR-based APIs that make it possible to deliver the information within the workflow of healthcare organizations’ care management or EHR systems. “The definition of success for us would be not that [an organization] is logging in to our portal,” Kates said, “but that they’re delivering better patient care more efficiently within the workflow that they’re using to care for their patients.”

The infrastructure is also making it possible for Manifest MedEx to grow. In fact, the nonprofit will soon add additional payer data covering an estimated 15 million lives. “We’re massively expanding the scope,” Kates said, “not only adding this claims data, but also going out and adding more provider organizations and more extended care, long-term care, skilled nursing facilities, and palliative care.”

To encourage more organizations to join, Manifest MedEx will continue to focus on results. Unlike other states, there is no universal mandate in California requiring “providers or health plans to participate in our organization,” Galvez said. “By and large, the decision to engage in our network is voluntary. So we have to deliver value to our customers in order for them to say, ‘I want to be part of this. I want to put data into it, and I want to take data out.’”

In the final analysis, by providing this value to healthcare organizations, Manifest MedEx is looking to make good on its promise to provide every healthcare organization across the state of California with the information that it needs to improve care and ultimately succeed under value-based care models.

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