Adrian Zai, MD, Clinical Director of Population Informatics at Massachusetts General Hospital (MGH) and a speaker at the 2015 Healthcare Information and Management Systems Society (HIMSS), describes his approach to improving population health and the role IT and InterSystems HealthShare® informatics platform play in it. He argues that improving population health is all about enabling the cycle of continuous improvement, which requires system interoperability. He presents a case study in which Partners Healthcare, which includes MGH, improves patient outcomes.