Mark Pasquale, CEO of the Missouri Health Connection (MHC) and a guest speaker at the 2015 Global Healthcare Leadership Conference, stresses the importance of Calculating Return on Investment (ROI) in a health information exchange (HIE). Pasquale uses a spreadsheet template to demonstrate how MHC, an InterSystems HealthShare® user, reduces emergency department visits, medication errors, readmissions, and malpractice litigation costs.